![]() ![]() Playthrough videoĬheck out the video of my less-than-impressed wife and I playing it. It’s a hell of a lot of fun but only with the less serious of your mates. Genital Jousting will have you cringing and laughing at very regular intervals. ![]() Multiple game modes provide a stimulating orgy of objectives: penetrate and be penetrated as fast as possible or compete in absurd, silly. Players control a detached penis complete with testicles and an anus. With the game, it is very easy to get your piece where you want it. Genital Jousting is an online and local multiplayer party game about flaccid penises and wiggly anuses for up to eight players at once. The game handles well and after a wee while. You want to play this with mates, laughing your heads off the entire time. It’s a pretty good way to hone your skills but is essentially the weaker of the two main modes. You complete tasks such as brushing your ‘teeth’, having a shower and all sorts of other mini-game type situations. There’s also a single player story mode which has you play as ‘John’ in his attempt at finding a date for his upcoming school reunion. Playing with friends either in person or online is absolutely hilarious! Flop it around, eat things with your posterior, it’s weird, it’s fun and it’s an absolute crack up. If this is something that makes you uncomfortable or sounds unappealing, please do not purchase or play Genital Jousting, or even continue reading. In multiplayer mode, you play various mini-game type modes including a date night! This is where the game is at its best. ![]() Due to party game mode, you can play a variety of game modes and joust with your friends. If you are reading this as a teenager you will love it, but don’t expect your parents to be so thrilled! Multiplayer In the party game Genital Jousting, you are required to play as a weirdly shaped responsive being that thrusts itself at the other characters. This is most definitely an R18 experience. You are essentially a cock and balls with a butthole thrown in for good measure. The team at Free Lives are freakin’ weirdos, and I love it! From the team previously known for their widely acclaimed platformer Broforce, comes the rude and crude Genital Jousting. I tested the limits of my marriage (video below). Genital Jousting is funny as hell and is best served as a multiplayer: laugh out loud with mates experience. ![]()
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![]() Normal rabbit IgG was purchased from Santa Cruz Biotechnology (Santa Cruz, CA). Antihuman retinoblastoma protein (Rb) monoclonal antibody (mAb) (G3-245), fluorescein isothiocyanate (FITC)–conjugated anti–underphosphorylated-Rb mAb (clone G99-549), FITC–antihuman cyclin D1/D2/D3 mAb (clone G124-259), FITC–anti-Ki-67 mAb (clone B56), FITC–antimouse Ig, FITC-mouse IgG1 and 7-AAD (Via Probe) were obtained from BD Pharmingen (San Diego, CA). 18 Monoclonal antihuman survivin antibody (6E4) was purchased from Cell Signaling (Beverly, MA). We previously described the specificity of the AF886 survivin antibody for intracellular staining in CD34 + cells. Affinity purified antihuman survivin polyclonal antibody (AF886) and mouse IgG 1 were purchased from R&D Systems (Minneapolis, MN). Recombinant murine GM-CSF was purchased from BioVision (Palo Alto, CA). Recombinant human and mouse stem cell factor (SCF) were a gift from Dr Karl Nocka, UCB Research (Cambridge, MA). ![]() Recombinant human granulocyte-macrophage colony-stimulating factor (GM-CSF), Flt3 ligand (FL), and thrombopoietin (Tpo) were provided by Immunex, Seattle, WA. These studies provide further evidence that survivin up-regulation by growth factors is not a consequence of cell cycle progression and strongly suggest that survivin is an important early event for cell cycle entry by CD34 +cells. An antisense survivin construct decreased total and S-phase CFU-GM. Retrovirus transduction of survivin-internal ribosome entry site–enhanced green fluorescent protein (survivin-IRES-EGFP) in primary mouse marrow cells increased granulocyte macrophage–colony-forming units (CFU-GM) by 1.7- to 6.2-fold and the proportion of CFU-GM in S phase, compared to vector control. Selective inhibition of the PI3-kinase/AKT and mitogen-activated protein kinase (MAPK p42/44) pathways blocked survivin up-regulation by growth factors before arresting cell cycle. Quantitative real-time reverse transcription–polymerase chain reaction (RT-PCR) and multivariate flow cytometry demonstrated that Tpo, SCF, and FL increase survivin mRNA and protein in quiescent G 0 CD34 +cells without increasing Ki-67 expression, indicating that cytokine-stimulated up-regulation of survivin in CD34 +cells occurs during G 0, before cells enter G 1. Up-regulation of survivin by thrombopoietin (Tpo), Flt3 ligand (FL), and stem cell factor (SCF) occurred in underphosphorylated-retinoblastoma protein (Rb) positive, Ki-67 negative, and cyclin D negativeCD34 + cells. Survivin expression is coincident with cell cycle progression. Analysis of known human IAPs revealed that only survivin is cytokine regulated in CD34 + cells. Herein, we examined survivin expression in CD34 + cells before and after cell cycle entry and demonstrate a role for survivin in cell cycle regulation and proliferation. We previously reported that survivin is expressed and growth factor regulated in normal adult CD34 + cells. The inhibitor of the apoptosis protein (IAP) survivin is expressed in proliferating cells such as fetal tissues and cancers. ![]() ![]() ![]() A show about an African lady detective was not as popular as grimdark fantasy with nekkid chicks - go figure. all seven episodes of it before it was canceled. If you like the books, you will like the TV series. It was obviously produced by people who were actually fans of the books, and it's definitely worth Netflixing. ![]() The first half dozen episodes feature stories from the first book mixed with a few others. This 2008 series benefited from HBO's high production values, and it was actually filmed in Botswana. As suggested in my cautionary note above, it's hard to tell whether the "African" elements - poisonous snakes and crocodiles, many mentions of cattle as a measure of wealth, and a crime boss who uses the services of a witch doctor - are "real Botswana" or "literary Botswana." I mean, obviously there are poisonous snakes, crocodiles, cattle, organized crime, and witchcraft in Botswana, but are these really things the average person there considers commonplace, or are you reading a collection of charming cliches for the delectation of foreign readers? I dunno, all I can say is that I enjoyed the book. 1 Ladies' Detective Agency is really a series of short stories, told mostly in a humorous fashion, though a few of them begin to touch on less humorous topics, like domestic violence and abducted children. Nothing in the book raised red flags for me, and I thought his treatment was respectful and sympathetic without being patronizing, but I've been burned before thinking a foreigner writing about another country did a fine job when according to the people living there now, it was, uh, not so great. I know precisely nothing I can't scrape off of Wikipedia about Botswana, so I cannot attest to how well Alexandra McCall Smith, a Zimbabwe-born Scottish author, portrayed a country he's lived in but is not a citizen of, from the POV of an African woman. I liked this first book very much and thought Precious was wonderful and the stories were warm and mostly cheerful, but with just enough seriousness to keep them out of "cozy" territory, and just enough irony to keep them from getting schmaltzy. A woman who suspects the man who suddenly appeared at her home and told her to go make him a sandwich might not really be her long-lost father, as he claims. Fathers who want to monitor their teenage daughters. Women who want to know the truth about their philandering husbands (or say they do). Of course, they are not exactly big-ticket cases. Initially, there seems to be little demand for private detectives in Botswana, and none for a lady detective, but slowly, cases start trickling in. Precious is the sort of protagonist you don't see a lot of in popular genre fiction, and which lots of people say they want to see more of: she's an unabashedly fat black woman, she does not center her life around men, and she is not a "strong female character" in the sense of leaping into action with martial arts or paranormal abilities or guns blazing - just intuition, keen observational skills, and a sense of justice and humanity.Īfter having married a bad-boy trumpet player, a marriage which went the way of most such ill-thought marriages, Precious Ramotswe sells her inheritance from her father when he dies and uses it to start her own business, the No. 1 Ladies' Detective Agency is that it's set in Botswana, and the main character, Precious Ramotswe, is the only lady detective in the country. Over the years, I've enjoyed a handful of series with an interesting hook beyond "tormented hot dude/gal with a past Solves Crime!" The modern mystery genre is full of series based on such "hooks" - Navajo detectives, Samurai detectives, Stalinist KGB detectives, Victorian Egyptologist detectives, and so on. I like the occasional mystery, though I'm very much not a fan of cozies. 1 Ladies' Detective Agency is that rare novel that imparts a sage wisdom while inspiring hearty laughter and lasting smiles. Potentially philandering husbands, seemingly schizophrenic doctors, and a missing boy who may have been killed by witch doctors all compel Precious to roam about in her tiny van, searching for clues.Ĭhosen as a Top Ten Mystery by the Organization of Independent Booksellers, U.S.A., The No. But eventually, troubled people come to Precious with a variety of concerns. Mma "Precious" Ramotswe sets up a detective agency in Botswana on the edge of the Kalahari Desert, making her the only female detective in the country. It has since earned two Booker Judges' Special Recommendations and was voted one of the "International Books of the Year and the Millennium" by the Times Literary Supplement. This remarkably fresh and charming best seller took the world by storm upon its publication. ![]() ![]() ![]() Moneyhouse ∙ Neue Zürcher Zeitung AG ∙ www.moneyhouse. Since 2014, Moneyhouse has been a 100% subsidiary of the NZZ media group – which is the driving force behind the next steps to even better business information. Since 2020, Moneyhouse is part of the Neue Zürcher Zeitung AG and is managed as a brand of the NZZ. Since then, anyone who is searching for companies in Switzerland – or for the individuals who control their destinies – will find Moneyhouse. Moneyhouse was founded in 2001 as Credita Management AG and has been offering easy-to-understand online information from the commercial register since 2004. 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It veers towards more of a thriller vibe than the horror vibe that most games like Friday the 13th go for, but still offers plenty of scares and engaging gameplay.įocusing predominantly on online multiplayer (but still having a decent offering for single player content) this game has 10 unique classes, referred to in the game as Perks. Killing Floor 2 is a fun, chaotic addition to the world of horror-themed online shooters. It’s not the most visually stunning or unique game, but it does offer a fun, adrenaline-fuelled experience. ![]() This is a great option for fans of games like Friday the 13th to check out. On the other hand, some can turn invisible, allowing them to sneakily approach the students or mess with their heads by moving around objects or opening doors. Some of the killers can use the environment to kill the students in surprising ways, such as suddenly smashing through windows and walls. As you might expect, each of them has various abilities that can be useful against teenagers in various ways. Each of them can create various items to fight the killer and escape.You can also choose from a few different killers to play as. There are also 4 different student classes: medic, assault, scout, and technician. For example, you can go to the science lab and try to build bombs you can use to fight the killers. If you decide to play as one of the teenagers, you’ll go through the school avoiding the killers while desperately trying to complete different objectives that can help you escape. ![]() Either play as one of the few teenagers who are trying to escape the serial killer that has occupied the school, or step into the shoes of the killer and hunt the students. The game revolves around a 1996 Halloween night in a classic horror movie high-school. And while Last Year: The Nightmare isn’t the most polished game on our list, it falls smack dab into the latter category of Friday The 13th clones, and it’s quite fun. The premise of Friday the 13th spawned plenty of games inspired by it and some straight-up clones. ![]() It’s one of the best games like Friday the 13th to check out today. Plus, you can play it on the Steam Deck in a dark bedroom for an added level of horror. You’ll find wood, dolls, matches, and keys that can help you fight her.Īll in all, while the graphics of the game are a little clunky, it’s quite fun. However, there’s a catch, you can play against or with your buddies! Just make sure to stay as quiet as you can, and keep yourself out of sight the girl can see and hear you almost everywhere. On the other hand, you’ve got an even more fun multiplayer mode as well where you can join with up to three other players. Is she completely evil or is there some actual good left in her? You’ll need to learn more and then succeed in pacifying (get it?) her to escape the house of horrors.Īs the game progresses, dealing with the girl becomes more and more difficult, and it’s even harder if you decide to play by yourself in single-player mode. However, soon enough you realize that a specter of a little girl haunts the house. ![]() In that role, you’re set loose in a dark, and mysterious house with the goal of exploring it for any paranormal activity. In this game, you play the role of an investigator working for PAH - Paranormal Activity Helpers. If you’re looking for a horror multiplayer classic that reminds you of Friday the 13th, look no further than Pacify. ![]() ![]() With Adobe Express, your creativity will follow you everywhere you go. 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Find & Download Free Graphic Resources for Aesthetic Poster. ![]() ![]() ![]() What it did have was speed, maze-like 3D levels and a range of movement in all directions that was at beautiful odds with the limited space in which to manoeuvre.ĭisorientation was a constant companion - for some players so, too, was motion sickness - but in rescuing trapped colonists otherwise doomed to die and escaping each quaking level before it was engulfed in a nuclear fireball the game paid out in full. ![]() ![]() True, it didn't have many rock star developers working on it, there were no demons from hell rampaging through it's claustrophobic corridors and there was not one smear of blood to enrage or delight its audience. Having been lumped in with run-and-gun first-person shooters since the time of its release (CGW magazine called it "Doom on Benzedrine in a vacuum"), Descent's numerous innovations have often been serially overlooked. What else should I be playing if I like this: There's been no shortage of Descent-style games recently, including Sublevel Zero, Retrovirus and NeonXSZ, and we're big fans of Overload and Blast-Axis, too. And don't listen to the naysayers, the final game drops the ball a bit during the closing act, but otherwise it's a cracking end to the trilogy. ![]() The middle game might be the best, but the first lays all the groundwork. And being the boss largely means telling people what to do - and snogging.Ĭommander Shepard's second mission remains their best - it's a planet-hopping Argonautica and suicide mission with some of BioWare's best-realised characters - but now the entire trilogy has been remastered as part of the Legendary Edition, there's really no reason not to play the whole lot from start to finish. You're not Sulu, blowing Klingons out of space, or Chekov, piloting a ship you're the boss. The Mass Effects are Captain Kirk simulators. What else should I be playing: Mass Effect wouldn't exist without Star Wars: Knights of the Old Republic, which saw BioWare bid farewell to Dungeons & Dragons and head into space for the first time. Where can I buy it: Steam, Humble, Origin Mass Effect Legendary Edition Developer: BioWare It's enormously entertaining, and its hand-crafted locations are some of the glossiest and most spectacular pockets of galaxy this side of No Man's Sky.ġ9. Just, you know, without the endless grind cycle. Each has their own special and passive abilities, and if it weren't for the flying around in space aspect, you could almost swear you're actually playing something like Diablo. While the first game was more of a roguelike, Everspace 2 ditches that structure for a more traditional action RPG that sees you gradually upgrading your ship with bigger and better parts and weapons grabbed from ships you've just obliterated with some well-executed laser beams.īattles are spectacular and frantic, but beneath the space fighting veneer, these ships are essentially behaving like your favourite RPG classes. Instead, try Chorus (the one whose logo looks like Chorvs), or Star Wars: Squadrons.Įverspace 2 is a classic arcade space shooter that feels like it's flown in through a wormhole from the early 00s. What else should I be playing: The first Everspace was a roguelike, so if it's arcade space shooting you're after, going backwards isn't advised. Disagree? Tell us about your favourite space game in the comments below, and maybe you'll convince others to give it a try.Ģ0. Plus, while there are still plenty of classics here, we've mainly focused on games we'd recommend you play today, rather than a 'greatest space games of all time' affair. Games about settling down on the surface of a new planet such as Surviving Mars and Astroneer, or those set in space-like locations such as Alien: Isolation aren't present in this list, as you never actually get to go to space while you're playing them. There are still plenty of hybrid games in our best space games list, from RPGs and space-themed strategy games, but almost all of them are about being in space, whether that's hurtling across the universe in a ship of some kind, or wafting around in zero gravity. We've kept our definition of "space game" fairly traditional here. Whether you're a budding space cruiser captain, a wannabe space conqueror or an intrepid space-faring explorer, there's a space game for you. But what games have gone before them and staked their claim already on the dusty planet surface known as 'Best Space Games'? We reveal all below, with our carefully curated list of all the best space games you can play on PC right now. Video games are great at transporting us to different worlds, but none capture that feeling quite so perfectly as intergalactic space games - and 2023 looks set to be one of the biggest years for space games yet, with the launch of Starfield, Homeworld 3 and more all on the horizon. ![]() ![]() ![]() What we did take from the sea is a little - technology. Street See back for more information City State Zip Aoolo. ![]() Today, we set the cruise control on an endless grid of limited-access, multilane interstate. ![]() The compact disc, too, will someday be an antique, supplanted by a different technology (download to flash. Endless - A VISUAL ALBUM (8/19/16) | MASTERPIECE - Never Coming to Streaming! Frank Ocean 437 replies by soupy. Frank Ocean (born October 28, 1987) is an American singer/songwriter and member. Frank Ocean Endless Full album Download, zip format mp3 songs, free. ![]() ![]() ![]() There will still be testing, close monitoring and follow-up appointments – all, hopefully, to prevent readmission. The hospitalization has been full of setbacks and improvements, stints in the ICU and then back to the general care floor, vital signs bordering on the catastrophic but also triumphs of modern medicine and human ingenuity.Īnd although it is a very good sign that the patient is getting discharged, it doesn’t mean America (or the world) is entirely out of the woods. ![]() ![]() I think of the end of the public health emergency as my patient finally being discharged from the hospital after a lengthy illness. So, what does that mean? Throughout the pandemic, I have written several essays about the United States as if it were my own patient. WHO says Covid-19 is no longer a global health emergency Tedros Adhanom Ghebreyesus attends an ACANU briefing on global health issues, including COVID-19 pandemic and war in Ukraine in Geneva in 2022. CIBMTR uses de-identified data and is unable to associate reported treatment problems, adverse events, or corrections of information with a center, clinical trial, or healthcare provider.Director-General of the World Health Organisation Dr. If you have questions related to these tools, please submit a support ticket via CIBMTR Center Support or, if you have no access, email Contact your healthcare provider immediately for reports of problems with your treatment or problems with products received for your treatment. If you have trouble accessing the system after an account is created, please put in a support ticket via CIBMTR Center Support. The access granted is based on the role you are given in the system. The primary data manager or medical director at your site is able to create an account for you in the Network Partner Portal. To access the CIBMTR Portal and its applications, you must have an NMDP user account. PartnerShare: Visualize data in commercial partners’ data sets.Cord Blood Report: Access monthly predefined reports regarding the quality and safety of distributed cord blood units.1-Year Survival Calculator: Predict one-year survival for individual allogeneic HCT recipients.Financial Payments Dashboard: Download your center’s financial reimbursement reports related to SCTOD form payment, BMT CTN quarterly enrollment, and other study-related activities.DataOps Dashboard: Download data regarding COVID impacts, consecutive transplant audits, continuous process improvement memos, data requests, and transplant-center specific analysis.Center Volumes Portal: Preview, correct, and approve center volume data published on the HRSA website.Center Performance Analytics: Compare your center’s data to aggregated center data filtered by various factors, view your own one-year survival rate, or create and implement ad hoc queries. ![]()
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